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For patients who already have established atherosclerotic disease a prior heart attack, ischaemic stroke, or symptomatic peripheral arterial disease and who carry excess weight, the case for adding semaglutide to secondary prevention is now established. The European and American diabetes guidelines already say so in type 2 diabetes. SELECT pushes the same logic into patients without diabetes. The JACC meta-analysis suggests the benefit travels: with or without diabetes, with or without obesity, with or without chronic kidney disease. A few things the data do not yet say

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It is not a formal pharmacological classification