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When mice are given MOTS-c, they dont gain as much weight on a high-fat diet and they maintain muscle mass, run better on a treadmill, and are less likely to have muscle atrophy

The dose-response relationship was clear across the REDEFINE 2 trial's range of 0.3 mg to 4.5 mg weekly, with higher doses consistently producing greater weight reductions

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This means most of a high-dose supplement remains in the gastrointestinal tract, though the direct link to digestive symptoms is not well established

Reliable metabolic research requires reagents of the highest molecular stability