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Clinical Classification of Chronic Venous Disease C0: No visible or palpable sign of venous disease C1: Spider veins or reticular veins (veins that feed spider veins) C2: Varicose veins C3: Edema (swelling) C4: Changes in skin and tissues A: Pigmentation or eczema B: Thickening, hardening, swelling, redness, inflammation, scarring C5: Healed venous ulcer C6: Active venous ulcer Note: Some potential complications of venous disease, such as DVT, can occur even in people who have no overt signs

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The target and mechanism of small molecules are summarized in Table 1

Therapeutic Effects of Amino Acids in Liver Diseases: Current Studies and Future Perspectives

The peptide not only reduced pain severity but also decreased the duration and frequency of pain episodes, suggesting its potential as a therapeutic agent for chronic pain management 7

In cases where encapsulation efficiency is low, patients may not receive the intended dose of the drug, leading to suboptimal treatment efficacy [343]