You may have a deficiency if you are vegan, if you have other health conditions which mean you are unable to absorb it properly such as pernicious anaemia, you take disruptive medications such as antacids or other lifestyle factors such as alcohol intake
The phase of a trial reveals what stage the drug is in to get approval for a specific condition
Can these medications replace insulin
Your health history, budget, insurance, and tolerance for side effects should drive the decision more than any general ranking

Accelerates healing process of tendons, ligaments and bone1-3,5 Enhances general body repair and wound healing Protects against formation of scar tissue6 Protects and heals the digestive system (reflux, ulcers, Ulcerative Colitis, IBS, colitis)7-10 Heals mitochondrial damage Increases growth hormone receptors3 Prevents damage from insulin toxicity11 Reduces inflammation in autoimmune conditions12 Improves brain health and mood Reduces depression and anxiety13 Demonstrates comparable effects to antidepressants with no side effects14 Protects against medication dependence and withdrawal15 Promotes repair of neurons in the brain16 Induces healing from traumatic brain injury17 Reduces neural damage from toxins in Parkinsons disease and MS18,19 Decreases the effects of neurotoxins Blocks long term effects and damage from corticosteroid injections20 Balances neurotransmitter production in the brain4 Protects the cardiovascular system21,22 Promotes nerve healing even in traumatic nerve injury23 Improves response to viruses and allergens24 Counteracts damage from toxins, severe electrolyte disturbances and heart arrythmias25,26 Improves severe chronic conditions such as CHF27 Reduces damage from NSAIDs like ibuprofen or advil28,29 Fights off alcohol intoxication and aids in recovery of substance abuse30,31 Heals skin wounds, diabetic ulcers, fistulas32 Who Might Benefit from BPC 157

My A1C is 5.4 now