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491 The A deposition hypothesis suggests that the normal mechanism of A removal from the brain tissue of AD patients is disrupted, leading to the accumulation of toxic A in the brain tissue to form A plaques, 492 and when the accumulation reaches a certain level, it triggers a series of neurodegenerative processes, such as inflammation, oxidative stress, and the deposition of Tau proteins, 493 which ultimately leads to a series of clinical conditions of AD

[1, 2, 3, 4, 5] Key Facts Brand Names: Adipex-P, Lomaira, Qsymia (when combined with topiramate)

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ARC, arcuate nucleus of the hypothalamus

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