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In a comprehensive US administrative database from 2005 to 2008, GLP-1-based treatments, particularly sitagliptin and exenatide, were associated with a significantly increased risk of acute pancreatitis-related hospitalization in adults with T2DM [59], thereby reinforcing prior mechanistic experimental studies and spontaneous reports to the FDA suggesting a potential causal relationship
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Both semaglutide and alcohol consumption have been associated with acute pancreatitis, though the absolute risk with GLP-1 receptor agonists remains low in clinical trials and real-world data
Zare Z, Masteri Farahani R, Salehi M, Piryaei A, Ghaffari Novin M, Fadaei Fathabadi F, Mohammadi M, Dehghani-Mohammadabadi M
Dose and titration speed This is the single biggest variable
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