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Originally developed to treat type 2 diabetes by mimicking hormones that regulate blood sugar, the medication quickly became better known for its powerful impact on weight loss due to the way the same mimicking hormones affect appetite

PMID 436006

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Abbreviations TNBC: Triple-negative breast cancer BC: Breast cancer ER: Estrogen receptor PR: Progesterone receptor HER2: Human epidermal growth factor receptor 2 ACD: Accidental cell death PCD: Programmed cell death LCD: Lysosome-dependent cell death PAMPs: Pathogen-associated molecular patterns DAMPs: Damage-associated molecular patterns TNF: Tumor necrosis factor FasL: Fas ligand TRAIL: TNF-related apoptosis inducing ligand FasRs: Fas receptors TNFR1: Tumor necrosis factor receptor 1 DR4: Death receptor 4 DR5: Death receptor 5 DISC: Death-inducing signal complex ROS: Reactive oxygen species Cytc: Cytochrome C ATR: ATM and rad3-related CCL2: CC motif chemokine ligand 2 EMT: Epithelial mesenchymal transition CSC: Cancer stem cell CTL: Cytotoxic T-lymphocyte NLRP3: NOD-like receptor thermal protein domain associated protein 3 AIM2: Absent in melanoma 2 ASC: Apoptosis-associated speck-like protein containing a CARD PYD: Pyrin domain HIN200: Hematopoietic interferon-inducible nuclear 200 proteins CARD: Caspase recruitment domain LPS: Lipopolysaccharides DC: Dendritic cell RIPK: Receptor interacting protein kinase MLKL: Mixed lineage kinase domain-like HMGB1: High mobility group box-1 protein ATGs: Autophagy-related genes mTORC1: Mechanistic target of rapamycin complex 1 PI3K: Phosphatidylinositol 3 kinase LC3: Microtubule associated protein light chain 3 PE: Phosphatidylethanolamine STX17: Syntaxin-17 SNAP29: Synaptosome associated protein 29 VAMP8: Vesical-associated membrane protein 8 TFR1: Transferrin receptor FPN1: Ferroportin 1 LIP: Labile iron pool GPX4: Glutathione peroxidase 4 GSH: Glutathione IRP: Iron regulatory protein Nrf2: Nuclear factor erythroid 2-related factor 2 FADD: Fas-associated protein with death domain ZDHHC1: Zinc finger DHHC-type containing 1 AML: Acute myeloid leukemia HSPA5: Heat shock protein family A member 5 LSD1: Lysine-specific demethylase 1 TRAF6: TNF receptor-associated factor 6 MDR: Multiple drug resistance AC: Anomanolide C TIM-3: T cell immunoglobulin and mucin domain-containing protein 3 TAMs: Tumor-associated macrophages CAR-T: Chimeric antigen receptor T cell immunotherapy TCR-T: Receptor-engineered T cell MDSCs: Myeloid-derived suppressor cells VDAC: Voltage-dependent anion channel MAPK: Mitogen-activated protein kinase ERK: Extracellular regulated protein kinases JNK: C-Jun n-terminal kinase IAPs: Inhibitor of apoptosis proteins -GCS: -Glutamylcysteine synthetase RSL3: RAS-selective lethal 3 References Leon-Ferre RA, Goetz MP

With obesity rates climbing and associated mental health challenges becoming increasingly recognized, understanding the nuanced differences between these two treatments has never been more crucial