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For testing the difference in mean and median lifespan between groups, we used linear mixed model with linear quantile mixed-effects model, which included cage assignment as a random effect and batch as a covariate, respectively, using package nlme and lgmm in statistical software R

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HRT restores hormonal balance that affects metabolism HRTparticularly estrogen, sometimes with progesteronehelps restore the hormonal environment that supports healthy metabolism, fat distribution, and insulin sensitivity

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Research Background & Published Literature GHK-Cu was discovered by Dr