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Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)
Loren Pickart in 1973
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Cells at PDL3 were also used to serve as the minimally expanded control
The choice of how to give the injection depends on the patients health, the desired effect, and the doctors opinion
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