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Thrombospondin-1 (TSP1) has been shown to upregulate PD-L1 expression in osteosarcoma through activation of the STAT3 pathway, thereby impairing antitumor immunity (37)
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Herein, the barren group of urchins showed the largest variation, with the first principal component (PC1) accounting for 60.5% of the variance between groups when considering significantly altered metabolites
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2 Results 2.1 Pharmacokinetic studies of BPC157 in rats The effective dose of BPC157 for the treatment of various injuries in mice, rats, and rabbits ranges from 6 to 50 g/kg ( The mean (+SD) plasma concentration of BPC157 versus time curves following administration of various BPC157 doses in rats are shown in Figures 1AC, and the corresponding pharmacokinetic parameters are presented in Tables 1Tables 3
