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Drug development for refractory epilepsy: the past 25 years and beyond
Eligible studies included phase 24 randomized controlled trials (RCTs), post hoc RCT analyses, and comparative observational studies reporting kidney outcomes
Second, pharmacokinetic studies characterizing systemic GHK-Cu levels after various routes of administration (topical, injectable, oral with encapsulation) to determine whether therapeutically relevant tissue concentrations are achievable beyond the skin
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Notably, zearalenone (ZEN) disrupts oocyte-cumulus cell interactions, delays cell cycle progression, and induces cytoskeletal abnormalities
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