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Research on epithalamin and epithalon dates back to the 1980s, overseen mostly by Vladimir Khavinson, an accomplished scientist who is well-known for his pioneering work on other peptide bioregulators including Vilon

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It remains unclear whether the observed cerebral hypoperfusion in those at risk for development of ADRD is primarily a consequence of impairments in systemic vascular health or a result of reductions in in cerebral metabolism

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