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In such cases, the cause of the condition is genetically-influenced In most cases, Melanotic Macules of Oral Mucosa are asymptomatic and do not present any significant signs and symptoms
When ingested or injected, the GLP-1 drugs bind to receptors in the brain, stomach, liver and pancreas
However, an excessive immune response usually leads to severe tissue damage
Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]
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