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The measures included: Appendicular and trunk fat-free mass (proxy for lean muscle) Whole-body and trunk fat mass Body-fat percentage Waist-to-hip ratio Key Findings The researchers found that for every 1-unit reduction in BMI linked to GLP-1 mimicry: Fat mass decreased by ~7.9 kg Lean mass (muscle) decreased by ~6.4 kg Body-fat percentage dropped by ~4.5% In other words, fat loss exceeded muscle loss in both absolute and relative terms, which supports the use of GLP-1 drugs as a viable treatment for obesity

We do, however, see changes in UCK2 expression (Fig

& Meier, J.J

It can help with metabolic health

Clinical trials show retatrutide can produce more weight loss on average than most existing obesity medications

Two main metabolites of gentiopicroside detected in rat plasma by lc-tof-ms following 2,4-dinitrophenylhydrazine derivatization