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128 This reduction is partially mediated through the upregulation of NLK and BCL2, which may contribute to the functional impairment observed in NK cells during aging
however, details on the studies are limited and are not overly informative
Sekhon says
Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
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