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Assessment of risk of bias Due to the great disparity in study designs (clinical and basic research) available for each candidate biomarkers of interest, we did not use ROC curve analysis as a selection criterion to address robustness, but instead included the presence of at least one study per biological compartment including at least 30 individuals per group as a mandatory criterion

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10.1212/WNL.0b013e318221acd3 Neurology 152 ShinJ

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Use bacteriostatic water specifically

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Melatonin, together with vitamin D, stimulates neuronal stem cells to differentiate into oligodendrocytes, which are the cells in the brain that are responsible for myelination of the nerves in the brain

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(4) What is the follow-up protocol to monitor response and side effects

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The standard dose is 1 mL, which is 1000 mcg of Vitamin B12

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