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While the results show great promise, significant challenges remain in reducing algorithmic bias across demographic groups, validating performance with diverse external datasets, prospective clinical evaluations, standardization of performance metrics, and clear regulatory pathways towards deployment (203, 204)

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Cytosolic cysteine comes from only three sources: (1) from methionine via the methionine cycle and the transsulfuration pathway, (2) direct import into the cell from the plasma, and (3) from excess protein catabolism over protein synthesis

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