Disclosure: The author has lived experience of endometriosis
and (2) forms of vitamin E other than -tocopherol are actively metabolized and excreted
Weekend breaks on the oral route are a cost choice, not a studied protocol
Theres also a black box warning (the most serious prescription label by the FDA) for a potential risk of thyroid C-cell tumors
The financial loss is real but less costly than running an entire protocol on degraded compound
Some mutations can lead to various neurological conditions, including neonatal mitochondrial encephalopathy, sensorineural hearing loss, axonal neuropathy, and, less commonly, motor neuron disease ( Riboflavin also supports the antioxidant defense system by aiding the regeneration of other antioxidants, such as glutathione, from oxidized glutathione (GSSG), since riboflavin, in the form of FAD, is necessary for glutathione reductase to play its role in converting GSSG (43)