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Authors' contributions: JS and DF participated in the conception and design of the review, revised the whole manuscript, and read and approved the final manuscript

Hydroxyurea therapy is a big old pill, and these hospitals have pediatric sickle cell patients, five-year-olds with sickle cell, Brunner said

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There is therefore a continued need to explore new biological pathways that could lead to improved or complementary treatment strategies, Kragstrup continued

Simulations suggest that glutathione pools are most sensitive to exposure duration at pharmacologically and supra-pharmacologically relevant doxorubicin concentrations

A sudden increase in dosage may cause severe stomach upset, which could irritate the stomach lining and make ulcers more likely