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The innate repair receptor (IRR) is a heterodimer of the EPO receptor and beta common receptor (CD131)

Note any changes in morning energy, afternoon slumps, or exercise performance

One panel member abstained from voting

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REDEFINE 1 -- CagriSema phase 3 (Aronne et al., 2025): CagriSema 2.4/2.4 mg produced 22.7% mean weight loss at 68 weeks vs 2.1% placebo

Robust Phase 2/3 studies are still lacking and most of the evidence remains preclinical