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Discovery of crotonylation modification In 2011, the Zhao team at the University of Chicago employed high-resolution mass spectrometry to first identify crotonylation modifications on histone H3 (Tan et al
The results indicate a protective role of GSTP1 by enhancing GSH-conjugation, which might lead to a reduced protein modification, and suggest a second protective role by interfering with the unfolded protein response, thereby preventing apoptosis

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Its worth noting that these positive effects were only seen in patients taking long-acting GLP-1 receptor agonists (more commonly prescribed) and not in those using short-acting agents