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Because most trials do not screen for binge-eating symptoms, the available evidence likely reflects populations with mixed characteristics, and specific data for BED remain limited

Becker, J

The glucagon component likely drives the liver fat reduction and lipid improvements beyond what GLP-1/GIP alone can do

That one change ripples outward, shifting gas production, water reabsorption, and the balance of gut bacteria, which is why digestive symptoms are so common in the first few months of treatment

This cycling approach prevents potential receptor desensitization and maintains effectiveness for subsequent cycles