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Fu Q, Levine BD

We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

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Clinical studies have shown that reduced glutathione concentration and/or a disproportionate ratio of GSH:GSSG [glutathione to oxidized glutathione] has been associated with a number of diseases, including cancer, human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), hepatitis, type 2 diabetes, Parkinsons disease, and cystic fibrosis (Allen & Bradley, 2011)