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Benoist, Caroline C et al
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A 2025 JAMA Neurology trial (n=1,500) demonstrated a 15-20% reduction in Hamilton Depression Rating Scale (HDRS) scores in deficient adults (serum B12 200 pg/mL and methylmalonic acid (MMA) 0.4 mol/L), with higher doses compensating for poor absorption or severe symptoms like megaloblastic anemia and neuropathy
B3 (niacin), B12s energy boost is mitochondrial-specific, while B3 targets NAD+ synthesis
Vitamin B12 and periods are also known to be related in another way
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