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The waist circumference reduction of approximately 24.1 cm at the 12mg dose is particularly striking this represents a clinically meaningful change in visceral adiposity (fat around the organs) which is the component of obesity most strongly associated with cardiometabolic risk, independent of overall BMI

The cellular ROS/Superoxide detection assay kit was purchased from Abcam and carboxyfluorescein diacetate succinimidyl ester (CFSE) was from Invitrogen

Cui, Z., Hwang, S

Conflict of interest DVR has acted as a consultant and received honoraria from Boehringer Ingelheim, Eli Lilly, Merck, Novo Nordisk and Sanofi and has received research operating funds from the Boehringer IngelheimEli Lilly Diabetes Alliance, MSD, AstraZeneca and Novo Nordisk

A 1-month supply costs $34.99

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