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The researchers also suggested that The enhancement of wound closure was more pronounced (median of 89.2% compared with -10.3% for vehicle

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Specifically, an initial reduction followed by a substantial increase in beta-endorphin levels was observed, a pattern that suggests DSIPs impact on the opioidergic system, potentially playing a role in stress alleviation or adaptation processes

10.1177/0748730406293854 J

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Moreover, GHK-Cu significantly inhibited the LPS-induced phosphorylation of p38 MAPK and slightly decreased the phosphorylation of JNK1/2, while having no observable effect on ERK1/2