While short-term insulin sensitivity changes are usually minor, the picture with decades of use is unclear
More recently, Iwata et al
541,542 Finally, aged astrocytes were reported to increase synthesis and release of GABA, which may impair excitation-inhibition balance on the neuronal networks
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It did stress the importance of reporting suspected side effects and adverse incidents to the Yellow Card scheme, adding that it "engages regularly with the MHRA and disseminates information on drug safety to healthcare professionals, including recent MHRA guidance on the safe use of GLP-1 medicines"
Depending on the patients needs, their doctor may adjust their dosage