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We next performed a structural similarity search across our in-house compound collection, as well as on commercial small-molecule libraries (1,000,000 compounds) and identified 141 additional hits, which were screened in the high-throughput activity assay at a single concentration of 10 M

Metabolism 49 , 38 (2000)

10.1021/acs.jproteome.0c00646 196

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Collectively, these findings underscore that cigarette smoking is not only associated with an increased risk of developing PBC but also accelerates disease progression, worsens fibrosis, elevates HCC risk, and contributes to poorer long-term outcomes

Because these nerve fibers have GLP-1 receptors, GLP-1 can influence how taste is detected and processed, which may help explain why many people notice changes in their food preferences while taking GLP-1 medications," explains Sun Jones, a board-certified family nurse practitioner and curriculum manager at the University of Phoenix College of Nursing