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The most commonly reported side effects are mild nausea, stomach upset, or a fishy body odor at higher oral doses (caused by trimethylamine production)

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Separately, a hip-fracture recovery trial in patients over 80 was terminated early after 6.5% of MK-677 recipients developed congestive heart failure versus 1.7% on placebo, alongside elevated blood pressure and glucose

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The age-related decline in the ability to synthesize GSH results in not only lower basal levels of GSH, but also a decreased adaptive response to CS