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[1] [2] The primary indications remain type 2 diabetes mellitus and obesity management in carefully selected patients

In large clinical trials, GLP-1 receptor agonists have been shown to reduce major cardiovascular events, things like heart attack and stroke, in people at elevated risk

Researchers studying the role of dual incretin signaling may prefer tirzepatide, which provides a direct way to study GLP-1/GIP interaction effects

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Eli Lilly developed tirzepatide for type 2 diabetes (Mounjaro, FDA-approved 2022) and later for chronic weight management (Zepbound, 2023)