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It isnt hyperbole to describe Ozempic and Wegovy as game changers. Over the past decade, GLP-1 agonists have emerged as a viable quick fix to one of the most complex public health problems of recent times

Abbreviations DM2: diabetes mellitus type 2 GCR: glucagon receptor GIPR: glucose-dependent insulinotropic peptide receptor GLP-1a: glucagon-like peptide-1 analogues HbA1c: glycated hemoglobin HCC: hepatocellular carcinoma MRI-PDFF: Magnetic Resonance Imaging-Proton Density Fat Fraction NAFLD: Non-alcoholic fatty liver disease NASH: non-alcoholic steatohepatitis NCT: National Clinical Trial number PPAR: Peroxisome Proliferator-Activated Receptor RCT: randomized clinical trial SGLT-2i: sodium-glucose co-transporter-2 inhibitors Declarations Funding None to declare

c-Met signaling plays a key role in neuronal survival, synaptic plasticity, and cognitive function

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In terms of R & D competitors, Amgen's MariTide has achieved once - a - month administration

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