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In addition to complex damaging glutamate excitotoxic mechanisms, excitotoxic glutamate inhibits mTOR signalling and causes elevated neuronal insulin resistance (Pomytkin et al

Kraft M, Kraft K, Gartner S, Mayerle J, Simon P, Weber E,

parkeri intracellular survival, we observed infection with immunofluorescence microscopy using a Zeiss 900 with Airyscan 2 detector that enables super-resolution imaging

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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels

Although our cerebral GSH results do not support the redox hypothesis of autism in the brain, previous results of decreased GSH in the plasma of autistic children may help explain some other inflammatory symptoms that autistic children experience (e.g