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These molecules are primarily formed in mitochondria during respiration, but additional sources include redox metal ions and enzymatic reactions [24]

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In addition, we used an alternative protocol in new set of experiments where we studied (in the presence of cilostamide) the effect of retatrutide, ryanodine, and nifedipine or control on different muscle strips from the same patient head to head: we first gave cilostamide, then added 10 nM ryanodine, and then added retatrutide (Fig