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The essential global gene expression regulator, HsrA, has been shown recently to be a promising target for drug development (Gonzlez et al

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7A), synapses with narrow synaptic clefts and sharply defined, electron-dense postsynaptic densities (PSDs), and presynaptic terminals containing abundant synaptic vesicles (SVs) clustered near active zones (Fig

Earlier initiation may be appropriate when significant comorbidities persist, but timing should be individualized based on surgical procedure type and metabolic status

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