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This process is mediated through the PI3K/Akt pathway, which enhances neurogenesis and promotes neuronal survival

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However, many peptides work locally, never reach the blood stream, and would never be called hormones

10.1126/science.1123511 22 BordetT.BuissonB.MichaudM.DrouotC.GalaP.DelaageP.et al

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Belanger M, Allaman I, Magistretti PJ