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Verdict at a Glance Semaglutide is the established standard with three FDA approvals, massive clinical evidence, and proven cardiovascular outcomes

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NICE guidance recommends holistic care addressing both metabolic and psychological wellbeing, with evidence-based anxiety treatments remaining the gold standard

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Nat Commun 15(1):5912 Mosterd CM, Bjornstad P, van Raalte DH (2020) Nephroprotective effects of GLP-1 receptor agonists: where do we stand