Under glucose-deprived conditions, the knockout of IDH1 or ME1 significantly reduces the NADPH/NADP+ and GSH/oxidized GSH ratios, leading to elevated ROS levels and increased cell death in cancer cells (94)
Detoxification: Glutathione plays an important role in removing toxins and heavy metals from the body
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Researchers have observed that deficiency in glutathione could be involved in the development of certain health issues including: Low glutathione levels have also been associated with premature aging
Vacuolar sequestration of glutathione S-conjugates outcompetes a possible degradation of the glutathione moiety by phytochelatin synthase
Studies also show that vegetarians and vegans are notoriously poor converters of ALA to DHA