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Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element

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Treatment may include CBT-I, sleep schedule support, mental health care, medication review, sleep apnea screening, circadian rhythm interventions, or other individualized options

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Cancer People who undergo chemotherapy (the primary treatment for most cancers) may receive milk thistle because chemo can lead to liver toxicity, particularly when it comes to treating acute lymphoblastic leukemia (ALL).22 In one study involving 40 patients with ALL undergoing chemotherapy, the researchers observed liver toxicity in 15% of subjects.23 Fortunately, milk thistle may be able to reduce the associated risk of mortality