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Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway
10.1007/s10787-017-0323-6 50 MihovilI.RadicB.BrcicL.BrcicI.VukojaI.IlicS.et al (2009)
Shortland GJ, Walter JH, Stroud C, Fleming PJ, Speidel BD, Marlow N
You cannot visually confirm contamination, and the risk of introducing bacteria into your reconstituted peptide is not worth the cost of a replacement vial
A health assessment matters
This effect was accompanied by a parallel accumulation of intracellular cAMP in ( B ) sAC +/+ caSMCs, but was lost in ( D ) sAC / caSMCs
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