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[Abstract] Chem Biol Interact
Among the five GST classes, the GSTA1 haplotype impact on CL exhibits age-dependency, reflecting the protein abundance of GSTAs in the liver increases after birth to reach adult levels during infancy (Strange et al., 1985
By design, MB affects redox status in red blood cells, and if misused, it can actually cause or worsen methemoglobinemia (particularly if overdosed) or precipitate hemolysis in G6PD-deficient patients
Toxicol Pathol 2007;35:495516
Freites-Martinez A, Santana N, Arias-Santiago S, Viera A
In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )
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