In Sept 2024, Terns Pharmaceuticals announced positive top-line results from its Phase 1 trial evaluating TERN-601 in healthy adults with obesity or overweight
For Ghana, this is a health story and an economic opportunity. We are a country where diabetes affects millions and the burden of cardiovascular disease continues to rise
Neurochem Res 14:12237, PMID: 2576463 Jenei Z, Janky R, Varga V, Saransaari P, Oja SS (1998) Interference of S -alkyl derivatives of glutathione with brain ionotropic glutamate receptors
Review of the potential mechanisms underlying the cardiovascular benefits of GLP-1RAs in T2DM patients
Furthermore, GLP-1Rs have been shown to be able to stimulate the depolarization-evoked release of other neurotransmitters, such as GABA and glutamate, as well as of serotonin and dopamine, in the cortex and hippocampus (Rebosio et al., 2018)
Side effects may return after a dose increase and then subside once more as the body adjusts