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Rapid depletion of endogenous UA reserves during severe ischemia leads to the failure of the natural antioxidant defense system, triggering the need for urgent exogenous UA supplementation for cerebral protection during acute stroke [150]

Clinical trial results concerning pancreas-related adverse effects have also been added The postmarketing experience section now includes reports of alopecia (hair loss) and dysesthesia (altered sense of touch)

While the medication can be effective, weight loss typically occurs gradually and requires consistency and patience

This can result in lower TMAO levels [60]

GABA may act as non-toxic osmolyte and scavenges ROS under the salt stress (Carillo 2018)