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Morciano, G

Epigenetic modification, unlike DNA mutations, is a reversible regulation

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doi: 10.1371/journal.pone.0305837 62 ChuaiG.MaH.YanJ.ChenM.HongN.XueD.et al

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Consistent with the above functional and biochemical findings, intracellular ROS levels assessed by DCFH-DA fluorescence staining showed that MAPKAPK2 overexpression markedly attenuated H2O2-induced ROS accumulation, reducing ROS levels by approximately 30%40% compared with the H 2 O 2 + vector group