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It can be the result of heredity, hairstyling practices, hormonal changes, medical conditions or a normal part of aging

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The overexpression of A20 was also shown to reduce lipogenesis and adipogenesis via lowering levels of sterol regulatory element binding protein-1c (SREBP-1c) and aP2, causing lower fat accumulation in differentiated 3T3-L1 cells [83]

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