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The GH-IGF-1 axis seems to play a role in certain cancers
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Seiler A, Schneider M, Frster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rdmark O, Wurst W, et al
A systematic review found no clinical safety data beyond a very small case series, emphasizing that the safety profile for chronic use in humans remains uncharacterized
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Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children ( Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism
