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Following the catabolism of glucose in the cytoplasm as part of glycolysis, the generated pyruvate is transported to the mitochondrial matrix, where it feeds into the TCA, undergoing oxidation to reduce NAD + to NADH, which is the main electron donor of the ETC 87

Understanding proper storage requirements is essential for patients using these medications, as improper handling can compromise treatment outcomes and represent a significant financial loss given the cost of these therapies

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95% CI: 1.11 114.4

PMID: 31550464

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