Oxidative stress caused by physical/emotional stress, strenuous exercise, exposure to environmental toxins, and immune stress can all cause an increase in free radicals, which may cause oxidative stress and deplete glutathione
Zhang J et al
Mortazavi H, Sabour S, Baharvand M, Manifar S, Akkafan R
Those same effects can reduce food and fluid intake
Effect of Spirulina platensis on growth, hematological, biochemical, and immunological parameters of Nile tilapia (Oreochromis niloticus)
Patients treated with arGLP-1 achieved a median weight loss of 11.7 kg, an increase in %TWL of 8.9% and 25.5% in %EWL, respectively, after 1 year of therapy