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Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

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Patients frequently report improvements in sleep onset, sleep depth, and morning restfulness within 2-4 weeks

This therefore increases the chances of misdiagnosis, delayed appropriate treatment, and poor clinical outcomes (De Sanctis et al

Covers the Russo 2013 decreased-HGF/GABA-in-OCD paper (the single most direct mechanistic link between Dihexas Read the full review Psychiatry & Mood Disorders 21 May 2026 Dihexa for Bipolar Disorder: Lithium Neuroprotection, BDNF/HGF, Caplyta & the 2026 UK Review Can Dihexa help bipolar disorder, bipolar depression or bipolar cognitive impairment

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