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Clinical efficacy data is from FDA-approved branded GLP-1 medications (Mounjaro, Zepbound, Wegovy, Ozempic)

If retatrutide produces better weight loss but costs significantly more, NICE may restrict it to specific patient groups while Mounjaro remains the first-line option

GLP-1 is an incretin hormone produced by intestinal enteroendocrine L cells in order to regulate glucose and energy homeostasis via GLP-1R binding and induction [9]

This leads to increased feelings of fullness, slower digestion, and reduced hungerhelping you eat less and lose weight over time

Semaglutide is best for those who struggle with constant hunger and intense cravings