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Everything needs to be in balance.[ref][ref] Prostate cancer risk is increased with 4-HOE1(E2) metabolites also.[ref] In general, the estrogen metabolites that start with 2 are good, and the ones that start with 4 or 16 need to be limited or at least eliminated quickly from the body.[ref] Here is a diagram of how these metabolites go together: As you can see, upregulating the CYP1A1 enzyme is going to increase the 2-OHE1 path

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2009 documented similar timelines in their photoaged-skin RCT 10

Vitamin C : This vitamin supports glutathione recycling and maintains levels in the body

Severe gastrointestinal disease or gastroparesis